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Structure paper

TitleThe design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 2337-2340, Year 2006
Publish dateJul 15, 2005 (structure data deposition date)
AuthorsHu, L.Y. / Boxer, P.A. / Kesten, S.R. / Lei, H.J. / Wustrow, D.J. / Moreland, D.W. / Zhang, L. / Ahn, K. / Ryder, T.R. / Liu, X. ...Hu, L.Y. / Boxer, P.A. / Kesten, S.R. / Lei, H.J. / Wustrow, D.J. / Moreland, D.W. / Zhang, L. / Ahn, K. / Ryder, T.R. / Liu, X. / Rubin, J.R. / Fahnoe, K. / Carroll, R.T. / Dutta, S. / Fahnoe, D.C. / Probert, A.W. / Roof, R.L. / Rafferty, M.F. / Kostlan, C.R. / Scholten, J.D. / Hood, M. / Ren, X.D. / Schielke, G.P. / Su, T.Z. / Taylor, C.P. / Mistry, A. / McConnell, P. / Hasemann, C. / Ohren, J.
External linksBioorg. Med. Chem. Lett. / PubMed:16143519
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2abj:
Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CBC:
N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / branched-chain-amino-acid aminotransferase / cytosolic / pyridoxal-phosphate-dependent aminotransferase / PLP-Lys220 Schiff base / inhibitor-bound

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