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TitleA Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 31283-31293, Year 2005
Publish dateJul 13, 2005 (structure data deposition date)
AuthorsBledsoe, R.K. / Madauss, K.P. / Holt, J.A. / Apolito, C.J. / Lambert, M.H. / Pearce, K.H. / Stanley, T.B. / Stewart, E.L. / Trump, R.P. / Willson, T.M. / Williams, S.P.
External linksJ. Biol. Chem. / PubMed:15967794
MethodsX-ray diffraction
Resolution1.75 - 2.2 Å
Structure data

PDB-2aa2:
Mineralocorticoid Receptor with Bound Aldosterone
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2aa5:
Mineralocorticoid Receptor with Bound Progesterone
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2aa6:
Mineralocorticoid Receptor S810L Mutant with Bound Progesterone
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2aa7:
Mineralocorticoid Receptor with Bound Deoxycorticosterone
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2aax:
Mineralocorticoid Receptor Double Mutant with Bound Cortisone
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-2ab2:
Mineralocorticoid Receptor Double Mutant with Bound Spironolactone
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-SO4:
SULFATE ION

ChemComp-AS4:
ALDOSTERONE / hormone*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-STR:
PROGESTERONE / hormone*YM

ChemComp-1CA:
DESOXYCORTICOSTERONE / hormone*YM

ChemComp-PDN:
17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE / medication*YM

ChemComp-SNL:
SPIRONOLACTONE / medication*YM

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Mineralocorticoid / MR / Nuclear Receptor / Steroid Receptor / Aldosterone / Mineralocorticoid receptor / Progesterone / Hypertension / Deoxycorticosterone / Cortisone / Spironolactone

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