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Structure paper

TitleAntiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Journal, issue, pagesCell. Mol. Life Sci., Vol. 62, Page 1763-1771, Year 2005
Publish dateJun 16, 2005 (structure data deposition date)
AuthorsKrystof, V. / McNae, I.W. / Walkinshaw, M.D. / Fischer, P.M. / Muller, P. / Vojtesek, B. / Orsag, M. / Havlicek, L. / Strnad, M.
External linksCell. Mol. Life Sci. / PubMed:16003486
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-2a0c:
Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-CK9:
2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / CELL CYCLE / PHOSPHORYLATION / CELL DIVISION / MITOSIS / INHIBITION / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING

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