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Structure paper

TitleUbC4 from Leishmania is a Druggable E2 Ubiquitin Conjugating Enzyme: Structural Basis and Fragment Hits for Future E2-Recruiting PROTAC Development
Journal, issue, pagesAcs Omega, Year 2026
Publish dateMar 20, 2026 (structure data deposition date)
AuthorsExertier, C. / Antonelli, L. / Liuzzi, A. / Ruffa, M. / Brufani, V. / Colotti, G. / Fiorillo, A. / Ilari, A.
External linksAcs Omega / Search PubMed
MethodsX-ray diffraction
Resolution2.001 - 2.37 Å
Structure data

PDB-29lm:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z104474512
Method: X-RAY DIFFRACTION / Resolution: 2.331 Å

PDB-29ln:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z111782404
Method: X-RAY DIFFRACTION / Resolution: 2.329 Å

PDB-29lo:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z1269184613
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

PDB-29lp:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z1428159350
Method: X-RAY DIFFRACTION / Resolution: 2.161 Å

PDB-29lq:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z1639162606
Method: X-RAY DIFFRACTION / Resolution: 2.001 Å

PDB-29lr:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z18197050
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-29ls:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z240654968
Method: X-RAY DIFFRACTION / Resolution: 2.219 Å

PDB-29lt:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z270760338
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

PDB-29lu:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z3765495818
Method: X-RAY DIFFRACTION / Resolution: 2.071 Å

PDB-29lv:
PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z55290386
Method: X-RAY DIFFRACTION / Resolution: 2.001 Å

Chemicals

ChemComp-IMD:
IMIDAZOLE

ChemComp-H04:
1-(2-ethoxyphenyl)piperazine

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ZTQ:
(2S)-2-[([1,1'-biphenyl]-4-yl)oxy]propanoic acid

ChemComp-Z2F:
1,3-benzothiazole-6-sulfonamide

PDB-1c9u:
CRYSTAL STRUCTURE OF THE SOLUBLE QUINOPROTEIN GLUCOSE DEHYDROGENASE IN COMPLEX WITH PQQ

ChemComp-PK4:
2-fluoro-N,3-dimethylbenzene-1-sulfonamide

ChemComp-RZG:
methyl 4-sulfamoylbenzoate

ChemComp-WNS:
N-(2-chloropyridin-3-yl)butanamide

PDB-1akb:
STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'-PHOSPHATE-BINDING LYSINE RESIDUE

PDB-1amz:
CHICKEN CITRATE SYNTHASE COMPLEX WITH NITROMETHYLDE-COA AND MALATE

ChemComp-LV1:
1-(4-fluorophenyl)-3-(3-hydroxyphenyl)urea

Source
  • leishmania major (eukaryote)
KeywordsLIGASE / Ubiquitin conjugating enzyme

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