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TitleSubstitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity.
Journal, issue, pagesEur. J. Biochem., Vol. 240, Page 331-335, Year 1996
Publish dateJul 22, 1996 (structure data deposition date)
AuthorsGao, Y.G. / Priebe, W. / Wang, A.H.
External linksEur. J. Biochem. / PubMed:8841395
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-276d:
SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-277d:
SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-278d:
SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-288d:
SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-DM8:
2'-BROMO-4'-EPIDAUNORUBICIN

ChemComp-HOH:
WATER

KeywordsDNA / RIGHT HANDED DNA / DOUBLE HELIX / COMPLEXED WITH DRUG / MODIFIED

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