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TitleRevolutionizing Anti-HIV Therapy: Targeted Degradation of Capsid by Host-Hijacking PROTAC Overcomes Drug Resistance
Journal, issue, pagesTo Be Published
Publish dateMay 7, 2026 (structure data deposition date)
AuthorsXue L / Gui J
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.8 Å
Structure data

80777

26nl

EMDB-80777, PDB-26nl:
Cryo-EM Structure of the HIV Capsid in Complex with VHL-3
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

PDB-1e9v:
XENON BOUND IN HYDROPHOBIC CHANNEL OF HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO VULGARIS

Source
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / HIV / Capsid / Inhibitor

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