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Structure paper

TitleOn the mechanism of hypomagnesimia with treatment-resistant seizures cansed by variants of the Na+,K+-ATPase alpha1 subunit (ATP1A1)
Journal, issue, pagesTo Be Published
Publish dateMar 17, 2026 (structure data deposition date)
AuthorsArtigas P / Abe K
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.61 Å
Structure data

69776

24rc

EMDB-69776, PDB-24rc:
Cryo-EM structure of human sodium pump W931R mutant in K+-occluded E2-Pi state
Method: EM (single particle) / Resolution: 2.61 Å

Chemicals

ChemComp-ALF:
TETRAFLUOROALUMINATE ION

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PCW:
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / DOPC, phospholipid*YM

ChemComp-CLR:
CHOLESTEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / P-type ATPase / sodium pump / mutant / micelle / hypomagnesimia

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