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Structure paper

TitleDe novo design of metalloproteases for targeted amyloid-beta cleavage
Journal, issue, pagesVita, Year 2026
Publish dateFeb 23, 2026 (structure data deposition date)
AuthorsQu Y / Wang C / Zhu H / Wang Y / Cao L
External linksVita / Search PubMed
MethodsEM (single particle)
Resolution2.98 - 3.5 Å
Structure data

69321

23wm

EMDB-69321, PDB-23wm:
Cryo-EM structure of the de novo designed metalloprotease PP507 E110Q mutant
Method: EM (single particle) / Resolution: 3.13 Å

69322

23wn

EMDB-69322, PDB-23wn:
Cryo-EM structure of the de novo designed metalloprotease DP622 E96Q mutant
Method: EM (single particle) / Resolution: 2.98 Å

69323

23wo

EMDB-69323, PDB-23wo:
Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant
Method: EM (single particle) / Resolution: 3.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsDE NOVO PROTEIN / de novo designed metalloprotease

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