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Structure paper

TitleStructure of chloramphenicol-bound MexB reveals residues in the distal binding pocket that are critical for substrate recognition.
Journal, issue, pagesJ. Biochem., Vol. 179, Page 403-411, Year 2026
Publish dateDec 11, 2025 (structure data deposition date)
AuthorsUeda, Y. / Yonehara, R. / Ishizaka-Ikeda, E. / Nakagawa, A. / Yamashita, E.
External linksJ. Biochem. / PubMed:41662826
MethodsX-ray diffraction
Resolution2.3 - 2.89 Å
Structure data

PDB-21fo:
CYMAL-7-bound MexB
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-21fp:
Chloramphenicol-bound MexB
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-CA7:
7-cyclohexylheptyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside

ChemComp-CLM:
CHLORAMPHENICOL / antibiotic*YM

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsMEMBRANE PROTEIN / Drug efflux / RND transporter

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