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TitleStructure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Journal, issue, pagesBiochemistry, Vol. 45, Page 12929-12941, Year 2006
Publish dateMay 13, 2005 (structure data deposition date)
AuthorsSingh, V. / Shi, W. / Almo, S.C. / Evans, G.B. / Furneaux, R.H. / Tyler, P.C. / Painter, G.F. / Lenz, D.H. / Mee, S. / Zheng, R. / Schramm, V.L.
External linksBiochemistry / PubMed:17059210
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-1zos:
Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-MTM:
(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL

ChemComp-HOH:
WATER

Source
  • streptococcus pneumoniae r6 (bacteria)
KeywordsHYDROLASE / nucleosidase / pneumoniae / transition state / inhibitor

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