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TitleIdentification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site
Journal, issue, pagesJ. Med. Chem., Vol. 47, Page 3537-3545, Year 2004
Publish dateMar 23, 2005 (structure data deposition date)
AuthorsKristiansen, M. / Andersen, B. / Iversen, L.F. / Westergaard, N.
External linksJ. Med. Chem. / PubMed:15214781
MethodsX-ray diffraction
Resolution2.03 - 2.4 Å
Structure data

PDB-1z6p:
Glycogen phosphorylase AMP site inhibitor complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1z6q:
Glycogen phosphorylase with inhibitor in the AMP site
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-194:
4-{2-[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID

ChemComp-HOH:
WATER

ChemComp-195:
4-{2,4-BIS[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / GLYCOGEN METABOLISM; GLYCOGEN PHOSPHORYLASE B; INHIBITION; allosteric

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