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TitleIndirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites
Journal, issue, pagesLETT. DRUG DES. DISCOVERY, Vol. 2, Page 377-390, Year 2005
Publish dateMar 21, 2005 (structure data deposition date)
AuthorsKosmopoulou, M.N. / Leonidas, D.D. / Chrysina, E.D. / Eisenbrand, G. / Oikonomakos, N.G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1z62:
Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-IAA:
({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / glycogenolysis / type 2 diabetes

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