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Structure paper

TitleSpecificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
Journal, issue, pagesMol. Cell, Vol. 18, Page 201-212, Year 2005
Publish dateMar 8, 2005 (structure data deposition date)
AuthorsMiller, G.J. / Wilson, M.P. / Majerus, P.W. / Hurley, J.H.
External linksMol. Cell / PubMed:15837423
MethodsX-ray diffraction
Resolution1.2 - 1.24 Å
Structure data

PDB-1z2n:
Inositol 1,3,4-trisphosphate 5/6-kinase complexed Mg2+/ADP
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-1z2o:
Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with mg2+/ADP/Ins(1,3,4,6)P4
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

PDB-1z2p:
Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with Mg2+/AMP-PCP/Ins(1,3,4)P3
Method: X-RAY DIFFRACTION / Resolution: 1.22 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-I4P:
(1S,3R,4R,6S)-1,3,4,6-TETRAPKISPHOSPHATE

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-I3S:
(1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL

Source
  • entamoeba histolytica (eukaryote)
KeywordsTRANSFERASE / Inositol phosphate kinase / ATP-grasp

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