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Structure paper

TitleCrystal structures of active SRC kinase domain complexes
Journal, issue, pagesJ. Mol. Biol., Vol. 353, Page 222-231, Year 2005
Publish dateJan 27, 2005 (structure data deposition date)
AuthorsBreitenlechner, C.B. / Kairies, N.A. / Honold, K. / Scheiblich, S. / Koll, H. / Greiter, E. / Koch, S. / Schaefer, W. / Huber, R. / Engh, R.A.
External linksJ. Mol. Biol. / PubMed:16168436
MethodsX-ray diffraction
Resolution1.95 - 2.9 Å
Structure data

PDB-1yoj:
Crystal structure of Src kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-1yol:
Crystal structure of Src kinase domain in complex with CGP77675
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1yom:
Crystal structure of Src kinase domain in complex with Purvalanol A
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-S03:
1-{4-[4-AMINO-5-(3-METHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL]BENZYL}PIPERIDIN-4-OL

ChemComp-P01:
2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL / inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein tyrosine kinase

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