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TitleSolution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH.
Journal, issue, pagesJ. Biomol. Nmr, Vol. 33, Page 69-72, Year 2005
Publish dateJan 10, 2005 (structure data deposition date)
AuthorsKovalevskaya, N.V. / Smurnyy, Y.D. / Polshakov, V.I. / Birdsall, B. / Bradbury, A.F. / Frenkiel, T. / Feeney, J.
External linksJ. Biomol. Nmr / PubMed:16222560
MethodsNMR (solution)
Structure data

PDB-1yho:
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Method: SOLUTION NMR

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-TRR:
2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM / antibiotic*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / DHFR / Inhibitor-Enzyme complex

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