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| Title | Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis |
|---|---|
| Journal, issue, pages | HELV. CHIM. ACTA, Vol. 88, Page 731-750, Year 2005 |
| Publish date | Dec 13, 2004 (structure data deposition date) |
Authors | Sahli, S. / Frank, B. / Schweizer, W.B. / Diederich, F. / Blum-Kaelin, D. / Aebi, J.D. / Bohm, H.J. / Oefner, C. / Dale, G.E. |
External links | HELV. CHIM. ACTA / Search PubMed |
| Methods | X-ray diffraction |
| Resolution | 2.25 Å |
| Structure data | ![]() PDB-1y8j: |
| Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-ZN: ![]() ChemComp-ACT: ![]() ChemComp-STS: ![]() ChemComp-HOH: |
| Source |
|
Keywords | HYDROLASE / LT1_6 |
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homo sapiens (human)
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