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Structure paper

TitleStructural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
Journal, issue, pagesStructure, Vol. 12, Page 2233-2247, Year 2004
Publish dateSep 30, 2004 (structure data deposition date)
AuthorsCard, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. ...Card, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. / Artis, D.R. / Bollag, G. / Milburn, M.V. / Kim, S.-H. / Schlessinger, J. / Zhang, K.Y.J.
External linksStructure / PubMed:15576036
MethodsX-ray diffraction
Resolution1.37 - 2.4 Å
Structure data

PDB-1xlx:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

PDB-1xlz:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-1xm4:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-1xm6:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-1xmu:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1xmy:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1xn0:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-1xom:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-1xon:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast
Method: X-RAY DIFFRACTION / Resolution: 1.72 Å

PDB-1xoq:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-1xor:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-1xos:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-1xot:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-1xoz:
Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
Method: X-RAY DIFFRACTION / Resolution: 1.37 Å

PDB-1xp0:
Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-CIO:
CILOMILAST / inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-FIL:
(1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME / inhibitor*YM

ChemComp-PIL:
3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE / antiinflammatory, inhibitor*YM

ChemComp-5RM:
(5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one

ChemComp-ROF:
3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE / medication, inhibitor*YM

ChemComp-ROL:
ROLIPRAM / antidepressant, inhibitor*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-ZAR:
6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE / anticancer, inhibitor*YM

ChemComp-SO4:
SULFATE ION

ChemComp-VIA:
5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE / medication*YM

ChemComp-VDN:
2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE / medication, inhibitor*YM

ChemComp-CIA:
6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE / medication*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE4B / Cilomilast / Filaminast / Piclamilast / (R)-Mesopram / Phosphodiesterase / PDE / Roflumilast / Rolipram / (R)-Rolipram / (R / S)-Rolipram / PDE4D / Zardaverine / Sildenafil / Viagra / Vardenafil / Levitra / PDE5A / Tadalafil / Cialis

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