EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
ジャーナル・号・ページ	Structure, Vol. 12, Page 2233-2247, Year 2004
掲載日	2004年9月30日 (構造データの登録日)
著者	Card, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. ...Card, G.L. / England, B.P. / Suzuki, Y. / Fong, D. / Powell, B. / Lee, B. / Luu, C. / Tabrizizad, M. / Gillette, S. / Ibrahim, P.N. / Artis, D.R. / Bollag, G. / Milburn, M.V. / Kim, S.-H. / Schlessinger, J. / Zhang, K.Y.J.
リンク	Structure / PubMed:15576036
手法	X線回折
解像度	1.37 - 2.4 Å
構造データ	PDB-1xlx: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-1xlz: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-1xm4: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-1xm6: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-1xmu: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-1xmy: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1xn0: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-1xom: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-1xon: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-1xoq: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å PDB-1xor: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-1xos: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-1xot: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-1xoz: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1xp0: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-MG: Unknown entry ChemComp-CIO: CILOMILAST / 阻害剤YM ChemComp-HOH: WATER ChemComp-FIL: (1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME / 阻害剤YM ChemComp-PIL: 3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE ChemComp-5RM: (5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one ChemComp-ROF: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE ChemComp-ROL: ROLIPRAM ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-B3P: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH緩衝剤YM ChemComp-ZAR: 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE / 抗がん剤, 阻害剤YM ChemComp-SO4: SULFATE ION ChemComp-VIA: 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE ChemComp-VDN: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE ChemComp-CIA: 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE / 薬剤*YM
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / PDE4B / Cilomilast / Filaminast / Piclamilast / (R)-Mesopram / Phosphodiesterase / PDE / Roflumilast / Rolipram / (R)-Rolipram / (R / S)-Rolipram / PDE4D / Zardaverine / Sildenafil / Viagra / Vardenafil / Levitra / PDE5A / Tadalafil / Cialis