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TitleNovel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 46096-46103, Year 2004
Publish dateAug 19, 2004 (structure data deposition date)
AuthorsDai, J. / Punchihewa, C. / Mistry, P. / Ooi, A.T. / Yang, D.
External linksJ. Biol. Chem. / PubMed:15317822
MethodsNMR (solution)
Structure data

PDB-1x95:
Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)
Method: SOLUTION NMR

Chemicals

ChemComp-XR2:
1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM

KeywordsDNA / anticancer drug / transcription inhibition / novel DNA binding / AP-1 / MLN944

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