EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
ジャーナル・号・ページ	J. Med. Chem., Vol. 57, Page 56-, Year 2014
掲載日	2004年9月20日 (構造データの登録日)
著者	Carbain, B. / Paterson, D.J. / Anscombe, E. / Campbell-Dexter, A. / Cano, C. / Echalier, A. / Endicott, J. / Golding, B.T. / Haggerty, K. / Hardcastle, I.R. ...Carbain, B. / Paterson, D.J. / Anscombe, E. / Campbell-Dexter, A. / Cano, C. / Echalier, A. / Endicott, J. / Golding, B.T. / Haggerty, K. / Hardcastle, I.R. / Jewsbury, P.J. / Newell, D.R. / Noble, M. / Roche, C. / Wang, L. / Griffin, R.J.
リンク	J. Med. Chem. / PubMed:24304238
手法	X線回折
解像度	2 - 3.5 Å
構造データ	PDB-1w8c: CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4cfm: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-4cfn: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4cfu: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4cfv: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4cfw: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-4cfx: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å
化合物	ChemComp-N69: 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE / 2-アミノ-6-シクロヘキシルメトキシ-8-イソプロピル-9H-プリン ChemComp-HOH: WATER ChemComp-4QE: 6-(cyclohexylmethoxy)-8-(2-methylphenyl)-9H-purin-2-amine ChemComp-JYM: 6-(cyclohexylmethoxy)-8-(trifluoromethyl)-9H-purin-2-amine ChemComp-DTT: 2,3-DIHYDROXY-1,4-DITHIOBUTANE / L-DTT ChemComp-2WC: 3-[2-azanyl-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methyl-benzoic acid ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-75X: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylphenol ChemComp-SQ9: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylbenzenesulfonamide ChemComp-G6T: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]benzenesulfonamide
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / CELL CYCLE / PHOSPHORYLATION / MITOSIS / INHIBITION / CELL DIVISION / CYCLIN DEPENDENT KINASES / STRUCTURE-BASED DRUG DESIGN / CONFORMATIONAL RESTRAINT / REVERSED BINDING MODE