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Title3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. Part 1. Lead Finding
Journal, issue, pagesJ. Med. Chem., Vol. 47, Page 3367-, Year 2004
Publish dateMay 7, 2004 (structure data deposition date)
AuthorsPevarello, P. / Brasca, M.G. / Amici, R. / Orsini, P. / Traquandi, G. / Corti, L. / Piutti, C. / Sansonna, P. / Villa, M. / Pierce, B.S. ...Pevarello, P. / Brasca, M.G. / Amici, R. / Orsini, P. / Traquandi, G. / Corti, L. / Piutti, C. / Sansonna, P. / Villa, M. / Pierce, B.S. / Pulici, M. / Giordano, P. / Martina, K. / Fritzen, E.L. / Nugent, R.A. / Casale, E. / Cameron, A. / Ciomei, M. / Roletto, F. / Isacchi, A. / Fogliatto, G. / Pesenti, E. / Pastori, W. / Marsiglio, A. / Leach, K.L. / Clare, P.M. / Fiorentini, F. / Varasi, M. / Vulpetti, A. / Warpehoski, M.A.
External linksJ. Med. Chem. / PubMed:15189033
MethodsX-ray diffraction
Resolution2.21 - 2.3 Å
Structure data

PDB-1vyw:
Structure of CDK2/Cyclin A with PNU-292137
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1vyz:
Structure of CDK2 complexed with PNU-181227
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-292:
N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE

ChemComp-HOH:
WATER

ChemComp-N5B:
N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / TRANSFERASE-COMPLEX / PROTEIN KINASE-COMPLEX / PROTEIN KINASE / SERINE/THREONINE-PROTEIN KINASE / PHOSPHORYLATION / CELL DIVISION / CYCLIN

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