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TitleIdentification of a potent and selective non-basic cathepsin K inhibitor.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 1985-1989, Year 2006
Publish dateMar 19, 2007 (structure data deposition date)
AuthorsLi, C.S. / Deschenes, D. / Desmarais, S. / Falgueyret, J.P. / Gauthier, J.Y. / Kimmel, D.B. / McGrath, M.E. / McKay, D.J. / Percival, M.D. / Riendeau, D. ...Li, C.S. / Deschenes, D. / Desmarais, S. / Falgueyret, J.P. / Gauthier, J.Y. / Kimmel, D.B. / McGrath, M.E. / McKay, D.J. / Percival, M.D. / Riendeau, D. / Rodan, S.B. / Truong, V.L. / Wesolowski, G. / Zamboni, R. / Black, W.C.
External linksBioorg. Med. Chem. Lett. / PubMed:16413777
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1vsn:
Crystal structure of a potent small molecule inhibitor bound to cathepsin K
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NFT:
N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / osteoporosis / structure-guided drug design / proteae

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