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TitleInhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.
Journal, issue, pagesBiochemistry, Vol. 40, Page 1861-1866, Year 2001
Publish dateAug 27, 2004 (structure data deposition date)
AuthorsKuzin, A.P. / Nukaga, M. / Nukaga, Y. / Hujer, A. / Bonomo, R.A. / Knox, J.R.
External linksBiochemistry / PubMed:11327849
MethodsX-ray diffraction
Resolution2.02 Å
Structure data

PDB-1vm1:
STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-MA4:
CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE

ChemComp-TBE:
TAZOBACTAM INTERMEDIATE

ChemComp-AKR:
ACRYLIC ACID

ChemComp-TAZ:
TAZOBACTAM / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • klebsiella pneumoniae (bacteria)
KeywordsHYDROLASE / Beta-LACTAMASE / BETA-LACTAM HYDROLASE / PENICILLINASE / DETERGENT Binding / Inhibitor design

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