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TitleMechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Journal, issue, pagesBiochemistry, Vol. 47, Page 9825-, Year 2008
Publish dateMar 20, 2008 (structure data deposition date)
AuthorsVetting, M.W. / Park, C.H. / Hegde, S.S. / Jacoby, G.A. / Hooper, D.C. / Blanchard, J.S.
External linksBiochemistry / PubMed:18710261
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-1v0c:
Structure of AAC(6')-Ib in complex with Kanamycin C and AcetylCoA.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2bue:
Structure of AAC(6')-Ib in complex with Ribostamycin and Coenzyme A.
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2vqy:
Structure of AAC(6')-Ib in complex with Parmomycin and AcetylCoA.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-ACO:
ACETYL COENZYME *A

ChemComp-KNC:
KANAMYCIN C

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-COA:
COENZYME A

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-PAR:
PAROMOMYCIN / medication*YM

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / GNAT / AMINOGLYCOSIDE / FLUOROQUINOLONE / ACETYLTRANSFERASE / ANTIBIOTIC RESISTANCE

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