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TitleBinding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.
Journal, issue, pagesEur. J. Biochem., Vol. 271, Page 2280-2290, Year 2004
Publish dateMar 16, 2004 (structure data deposition date)
AuthorsKosmopoulou, M.N. / Leonidas, D.D. / Chrysina, E.D. / Bischler, N. / Eisenbrand, G. / Sakarellos, C.E. / Pauptit, R. / Oikonomakos, N.G.
External linksEur. J. Biochem. / PubMed:15153119
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1uzu:
Glycogen Phosphorylase b in complex with indirubin-5'-sulphonate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-INR:
2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / GLYCOSYLTRANSFERASE / GLYCOGEN METABOLISM / CARBOHYDRATE METABOLISM / PYRIDOXAL PHOSPHATE

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