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TitleImidazo[1,2-B]Pyridazines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 14, Page 2249-, Year 2004
Publish dateNov 11, 2003 (structure data deposition date)
AuthorsByth, K.F. / Cooper, N. / Culshaw, J.D. / Heaton, D.W. / Oakes, S.E. / Minshull, C.A. / Norman, R.A. / Pauptit, R.A. / Tucker, J.A. / Breed, J. ...Byth, K.F. / Cooper, N. / Culshaw, J.D. / Heaton, D.W. / Oakes, S.E. / Minshull, C.A. / Norman, R.A. / Pauptit, R.A. / Tucker, J.A. / Breed, J. / Pannifer, A. / Rowsell, S. / Stanway, J.J. / Valentine, A.L. / Thomas, A.P.
External linksBioorg. Med. Chem. Lett. / PubMed:15081018
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-1urw:
CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-I1P:
2-[4-(N-(3-DIMETHYLAMINOPROPYL)SULPHAMOYL)ANILINO]-

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / MITOSIS

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