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Structure paper

TitleInhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.
Journal, issue, pagesFebs Lett., Vol. 556, Page 43-46, Year 2004
Publish dateAug 13, 2003 (structure data deposition date)
AuthorsKinoshita, T. / Nakanishi, I. / Warizaya, M. / Iwashita, A. / Kido, Y. / Hattori, K. / Fujii, T.
External linksFebs Lett. / PubMed:14706823
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-1uk0:
Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-FRM:
2-{3-[4-(4-FLUOROPHENYL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]PROPYL}-8-METHYL-4(3H)-QUINAZOLINONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Protein-inhibitor complex

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