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-Structure paper
Title | Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 13, Page 2141-2156, Year 2005 |
Publish date | Aug 10, 2004 (structure data deposition date) |
Authors | Choe, Y. / Brinen, L.S. / Price, M.S. / Engel, J.C. / Lange, M. / Grisostomi, C. / Weston, S.G. / Pallai, P.V. / Cheng, H. / Hardy, L.W. ...Choe, Y. / Brinen, L.S. / Price, M.S. / Engel, J.C. / Lange, M. / Grisostomi, C. / Weston, S.G. / Pallai, P.V. / Cheng, H. / Hardy, L.W. / Hartsough, D.S. / McMakin, M. / Tilton, R.F. / Baldino, C.M. / Craik, C.S. |
External links | Bioorg. Med. Chem. / PubMed:15727867 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-1u9q: |
Chemicals | ChemComp-186: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Clan-CA cysteine protease; covalent inhibitor |