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TitlePotent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions
Journal, issue, pagesBIOORG. MED. CHEM. LETT., Vol. 14, Page 4897-4902, Year 2004
Publish dateJun 24, 2004 (structure data deposition date)
AuthorsBarrett, D.G. / Catalano, J.G. / Deaton, D.N. / Hassell, A.M. / Long, S.T. / Miller, A.B. / Miller, L.R. / Shewchuk, L.M. / Wells-Knecht, K.J. / Willard, D.H. / Wright, L.L.
External linksBIOORG. MED. CHEM. LETT. / PubMed:15341947
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-1tu6:
Cathepsin K complexed with a ketoamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-FSP:
[1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / catk / cysteine protease

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