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Structure paper

TitleDiscovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 909-912, Year 2005
Publish dateApr 29, 2004 (structure data deposition date)
AuthorsGrasberger, B.L. / Lu, T. / Schubert, C. / Parks, D.J. / Carver, T.E. / Koblish, H.K. / Cummings, M.D. / LaFrance, L.V. / Milkiewicz, K.L.
External linksJ. Med. Chem. / PubMed:15715460
MethodsX-ray diffraction
Resolution1.9 - 2.6 Å
Structure data

PDB-1t4e:
Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1t4f:
Structure of human MDM2 in complex with an optimized p53 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-DIZ:
(4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsLIGASE / MDM2-Inhibitor complex / MDM2-p53 peptide complex / p53-binding protein Mdm2 Oncoprotein Mdm2 Double minute 2 protein Hdm2

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