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TitleThe ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 11, Page 863-867, Year 2004
Publish dateMar 22, 2004 (structure data deposition date)
AuthorsDementiev, A. / Petitou, M. / Herbert, J.M. / Gettins, P.G.
External linksNat. Struct. Mol. Biol. / PubMed:15311268
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-1sr5:
ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GU4:
2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEINASE INHIBITOR / ANTITHROMBIN ACTIVATION BY HEP ANHYDROTHROMBIN / PROTEIN-PROTEIN INTERACTIONS / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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