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Structure paper

TitleLoop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Journal, issue, pagesBiochemistry, Vol. 36, Page 586-603, Year 1997
Publish dateNov 28, 1996 (structure data deposition date)
AuthorsSawaya, M.R. / Kraut, J.
External linksBiochemistry / PubMed:9012674
MethodsX-ray diffraction
Resolution1.55 - 2.8 Å
Structure data

PDB-1dre:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1ra1:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1ra2:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1ra3:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1ra8:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1ra9:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-1rb2:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1rb3:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1rc4:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1rd7:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1re7:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1rf7:
STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1rg7:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1rh3:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1rx1:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1rx2:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1rx3:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1rx4:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1rx5:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1rx6:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1rx7:
STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1rx8:
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1rx9:
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MTX:
METHOTREXATE / chemotherapy*YM

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-FOL:
FOLIC ACID

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-ATR:
2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE

ChemComp-DDF:
5,10-DIDEAZATETRAHYDROFOLIC ACID

ChemComp-CL:
Unknown entry

ChemComp-MN:
Unknown entry

ChemComp-DHF:
DIHYDROFOLIC ACID

Source
  • escherichia coli (E. coli)
KeywordsOXIDOREDUCTASE / NADP / TRIMETHOPRIM RESISTANCE / METHOTREXATE RESISTANCE / ONE-CARBON METABOLISM / OXIDO-REDUCTASE NADP / OXIDO-REDUCTASE

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