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Structure paper

TitleRandom mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 17, Page 625-633, Year 2004
Publish dateOct 31, 2003 (structure data deposition date)
AuthorsMahan, S.D. / Ireton, G.C. / Knoeber, C. / Stoddard, B.L. / Black, M.E.
External linksProtein Eng. Des. Sel. / PubMed:15381761
MethodsX-ray diffraction
Resolution1.12 - 1.58 Å
Structure data

PDB-1r9x:
Bacterial cytosine deaminase D314G mutant.
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-1r9y:
Bacterial cytosine deaminase D314A mutant.
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-1r9z:
Bacterial cytosine deaminase D314S mutant.
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-1ra0:
Bacterial cytosine deaminase D314G mutant bound to 5-fluoro-4-(S)-hydroxy-3,4-dihydropyrimidine.
Method: X-RAY DIFFRACTION / Resolution: 1.12 Å

PDB-1ra5:
Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-1rak:
Bacterial cytosine deaminase D314S mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-FPY:
(4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / cytosine deaminase / alpha-beta barrel / hexamer / domain swap / D314G mutant / amino hydrolase / D314A mutant / D314S mutant / CONFORMATIONAL CHANGE

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