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TitleA structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 35638-35643, Year 2004
Publish dateOct 15, 2003 (structure data deposition date)
AuthorsBenarroch, D. / Egloff, M.P. / Mulard, L. / Guerreiro, C. / Romette, J.L. / Canard, B.
External linksJ. Biol. Chem. / PubMed:15152003
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1r6a:
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-RVP:
RIBAVIRIN MONOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • dengue virus 2 puerto rico/pr159-s1/1969
KeywordsTRANSFERASE / ribavirin 5'-triphosphate / dengue virus / 2'O methyltransferase

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