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Structure paper

TitleCrystal Structure of a Mutant Heralpha Ligand- Binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
Journal, issue, pagesJ. Biol. Chem., Vol. 276, Page 15059-, Year 2001
Publish dateAug 5, 1999 (structure data deposition date)
AuthorsGangloff, M. / Ruff, M. / Eiler, S. / Duclaud, S. / Wurtz, J.M. / Moras, D.
External linksJ. Biol. Chem. / PubMed:11278577
MethodsX-ray diffraction
Resolution2.2 - 3.2 Å
Structure data

PDB-1qkt:
MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1qku:
WILD TYPE ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-EST:
ESTRADIOL / hormone*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR RECEPTOR / AGONISM / ANTAGONISM / STEROID / STRUCTURAL PROTEOMICS IN EUROPE / SPINE / STRUCTURAL GENOMICS / ESTRADIOL RECEPTOR

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