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Structure paper

TitleStructure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Journal, issue, pagesEmbo J., Vol. 18, Page 4608-, Year 1999
Publish dateJul 27, 1999 (structure data deposition date)
AuthorsPike, A.C.W. / Brzozowski, A.M. / Hubbard, R.E. / Bonn, T. / Thorsell, A.-G. / Engstrom, O. / Ljunggren, J. / Gustaffson, J.-A. / Carlquist, M.
External linksEmbo J. / PubMed:10469641
MethodsX-ray diffraction
Resolution1.8 - 2.25 Å
Structure data

PDB-1qkm:
HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1qkn:
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH ANTAGONIST RALOXIFENE
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-GEN:
GENISTEIN / inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-RAL:
RALOXIFENE / medication*YM

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsNUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / PHYTO-OESTROGEN / PARTIAL AGONIST / ANTAGONIST

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