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-Structure paper
Title | Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates |
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Journal, issue, pages | J. Med. Chem., Vol. 47, Page 6556-6568, Year 2004 |
Publish date | Jul 25, 2003 (structure data deposition date) |
![]() | Venkatesan, A.M. / Gu, Y. / Dos Santos, O. / Abe, T. / Agarwal, A. / Yang, Y. / Petersen, P.J. / Weiss, W.J. / Mansour, T.S. / Nukaga, M. ...Venkatesan, A.M. / Gu, Y. / Dos Santos, O. / Abe, T. / Agarwal, A. / Yang, Y. / Petersen, P.J. / Weiss, W.J. / Mansour, T.S. / Nukaga, M. / Hujer, A. / Bonomo, R.A. / Knox, J.R. |
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Methods | X-ray diffraction |
Resolution | 1.4 - 2 Å |
Structure data | ![]() PDB-1q2p: ![]() PDB-1q2q: |
Chemicals | ![]() ChemComp-MA4: ![]() ChemComp-WY2: ![]() ChemComp-HOH: ![]() ChemComp-GOL: |
Source |
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![]() | HYDROLASE / inhibition / beta-lactam antibiotics / drug design |