+Search query
-Structure paper
Title | 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 47, Page 1662-1675, Year 2004 |
Publish date | Jul 4, 2003 (structure data deposition date) |
Authors | Wang, S. / Meades, C. / Wood, G. / Osnowski, A. / Anderson, S. / Yuill, R. / Thomas, M. / Mezna, M. / Jackson, W. / Midgley, C. ...Wang, S. / Meades, C. / Wood, G. / Osnowski, A. / Anderson, S. / Yuill, R. / Thomas, M. / Mezna, M. / Jackson, W. / Midgley, C. / Griffiths, G. / Fleming, I. / Green, S. / McNae, I. / Wu, S.Y. / McInnes, C. / Zheleva, D. / Walkinshaw, M.D. / Fischer, P.M. |
External links | J. Med. Chem. / PubMed:15027857 |
Methods | X-ray diffraction |
Resolution | 1.96 - 2.53 Å |
Structure data | PDB-1pxm: PDB-1pxn: PDB-1pxo: PDB-1pxp: |
Chemicals | ChemComp-CK5: ChemComp-HOH: ChemComp-CK6: ChemComp-CK7: ChemComp-CK8: |
Source |
|
Keywords | TRANSFERASE / PROTEIN KINASE / CELL CYCLE / PHOSPHORYLATION / CELL DIVISION / MITOSIS / INHIBITION / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / 3D-STRUCTURE. |