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-Structure paper
Title | Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates |
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Journal, issue, pages | J. Biol. Chem., Vol. 279, Page 18034-18045, Year 2004 |
Publish date | Apr 23, 2003 (structure data deposition date) |
Authors | Cheong, C.-G. / Wolan, D.W. / Greasley, S.E. / Horton, P.A. / Beardsley, G.P. / Wilson, I.A. |
External links | J. Biol. Chem. / PubMed:14966129 |
Methods | X-ray diffraction |
Resolution | 2.55 - 2.6 Å |
Structure data | PDB-1p4r: PDB-1pl0: |
Chemicals | ChemComp-K: ChemComp-AMZ: ChemComp-354: ChemComp-XMP: ChemComp-HOH: ChemComp-BW2: |
Source |
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Keywords | TRANSFERASE / HYDROLASE / antifolate / ATIC / purine biosynthesis / BW1540U88UD / human ATIC / AICAR / AICAR transformylase / IMP Cyclohydrolase / xanthosine monophosphate / folate-based inhibitor / BW2315U89UC |