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TitleAn aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 13, Page 3465-3470, Year 2003
Publish dateApr 23, 2003 (structure data deposition date)
AuthorsVelentza, A.V. / Wainwright, M.S. / Zasadzki, M. / Mirzoeva, S. / Schumacher, A.M. / Haiech, J. / Focia, P.J. / Egli, M. / Watterson, D.M.
External linksBioorg. Med. Chem. Lett. / PubMed:14505650
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1p4f:
DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-86Q:
5,6-Dihydro-benzo[H]cinnolin-3-ylamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase

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