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TitleDesign and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.
Journal, issue, pagesJ. Med. Chem., Vol. 46, Page 4702-4713, Year 2003
Publish dateApr 7, 2003 (structure data deposition date)
AuthorsTrejo, A. / Arzeno, H. / Browner, M. / Chanda, S. / Cheng, S. / Comer, D.D. / Dalrymple, S.A. / Dunten, P. / Lafargue, J. / Lovejoy, B. ...Trejo, A. / Arzeno, H. / Browner, M. / Chanda, S. / Cheng, S. / Comer, D.D. / Dalrymple, S.A. / Dunten, P. / Lafargue, J. / Lovejoy, B. / Freire-Moar, J. / Lim, J. / Mcintosh, J. / Miller, J. / Papp, E. / Reuter, D. / Roberts, R. / Sanpablo, F. / Saunders, J. / Song, K. / Villasenor, A. / Warren, S.D. / Welch, M. / Weller, P. / Whiteley, P.E. / Zeng, L. / Goldstein, D.M.
External linksJ. Med. Chem. / PubMed:14561090
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1oz1:
P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-FPH:
3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SER/THR PROTEIN KINASE

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