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Structure paper

TitleA chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
Journal, issue, pagesMol. Cell, Vol. 11, Page 1079-1092, Year 2003
Publish dateMar 19, 2003 (structure data deposition date)
AuthorsDownes, M. / Verdecia, M.A. / Roecker, A.J. / Hughes, R. / Hogenesch, J.B. / Kast-Woelbern, H.R. / Bowman, M.E. / Ferrer, J.-L. / Anisfeld, A.M. / Edwards, P.A. ...Downes, M. / Verdecia, M.A. / Roecker, A.J. / Hughes, R. / Hogenesch, J.B. / Kast-Woelbern, H.R. / Bowman, M.E. / Ferrer, J.-L. / Anisfeld, A.M. / Edwards, P.A. / Rosenfeld, J.M. / Alvarez, J.G. / Noel, J.P. / Nicolaou, K.C. / Evans, R.M.
External linksMol. Cell / PubMed:12718892
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1osh:
A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-FEX:
METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE / agonist*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Nuclear Receptor / Ligand Binding Domain

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