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TitleBiochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 32832-, Year 2004
Publish dateApr 3, 2003 (structure data deposition date)
AuthorsSchelling, P. / Claus, M.T. / Johner, R. / Marquez, V.E. / Schulz, G.E. / Scapozza, L.
External linksJ. Biol. Chem. / PubMed:15163659
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-1of1:
KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-SCT:
(SOUTH)-METHANOCARBA-THYMIDINE

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • herpes simplex virus (type 1 / strain 17)
KeywordsTRANSFERASE / THYMIDINE KINASE / ANTIVIRAL DRUG / ENZYME-PRODRUG GENE / KINASE / DNA SYNTHESIS / ATP-BINDING

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