Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
Journal, issue, pages	J. Med. Chem., Vol. 46, Page 5184-5195, Year 2003
Publish date	Jun 15, 2003 (structure data deposition date)
Authors	Lange, G. / Lesuisse, D. / Deprez, P. / Schoot, B. / Loenze, P. / Benard, D. / Marquette, J.P. / Broto, P. / Sarubbi, E. / Mandine, E.
External links	J. Med. Chem. / PubMed:14613321
Methods	X-ray diffraction
Resolution	1.5 - 2.25 Å
Structure data	PDB-1o41: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o42: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o43: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129. Method: X-RAY DIFFRACTION / Resolution: 1.5 Å PDB-1o44: Crystal structure of sh2 in complex with ru85052 Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o45: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687. Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-1o46: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395. Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-1o47: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209. Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-1o48: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053. Method: X-RAY DIFFRACTION / Resolution: 1.55 Å PDB-1o49: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o4a: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197. Method: X-RAY DIFFRACTION / Resolution: 1.5 Å PDB-1o4b: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876. Method: X-RAY DIFFRACTION / Resolution: 1.85 Å PDB-1o4c: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE. Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-1o4d: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262. Method: X-RAY DIFFRACTION / Resolution: 1.85 Å PDB-1o4e: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299. Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-1o4f: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073. Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-1o4g: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59. Method: X-RAY DIFFRACTION / Resolution: 1.55 Å PDB-1o4h: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072. Method: X-RAY DIFFRACTION / Resolution: 2.25 Å PDB-1o4i: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219. Method: X-RAY DIFFRACTION / Resolution: 1.75 Å PDB-1o4j: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o4k: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN. Method: X-RAY DIFFRACTION / Resolution: 1.57 Å PDB-1o4l: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. Method: X-RAY DIFFRACTION / Resolution: 1.65 Å PDB-1o4m: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID. Method: X-RAY DIFFRACTION / Resolution: 1.6 Å PDB-1o4n: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID. Method: X-RAY DIFFRACTION / Resolution: 1.6 Å PDB-1o4o: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o4p: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791. Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-1o4q: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256. Method: X-RAY DIFFRACTION / Resolution: 1.7 Å PDB-1o4r: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783. Method: X-RAY DIFFRACTION / Resolution: 1.5 Å
Chemicals	ChemComp-300: 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE ChemComp-HOH: WATER ChemComp-843: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE ChemComp-821: [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET ChemComp-852: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID ChemComp-687: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE ChemComp-903: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID ChemComp-822: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE ChemComp-853: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID ChemComp-493: {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID ChemComp-197: 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID ChemComp-876: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE ChemComp-PO4: PHOSPHATE ION ChemComp-262: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE ChemComp-299: 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE ChemComp-790: 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE ChemComp-I59: HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID ChemComp-772: 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE ChemComp-219: cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate ChemComp-IS2: [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID ChemComp-PSN: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE ChemComp-CIT: CITRIC ACID ChemComp-MLA: MALONIC ACID ChemComp-OXD: OXALIC ACID ChemComp-HPS: PHENYL DIHYDROGEN PHOSPHATE ChemComp-791: 2-PHENYLMALONIC ACID ChemComp-256: PHENYL(SULFO)ACETIC ACID ChemComp-787: (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID
Source	homo sapiens (human)
Keywords	SIGNALING PROTEIN / SH2 DOMAIN FRAGMENT APPROACH