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TitleCoactivator binding promotes the specific interaction between ligand and the pregnane X receptor
Journal, issue, pagesJ. Mol. Biol., Vol. 331, Page 815-828, Year 2003
Publish dateJan 25, 2003 (structure data deposition date)
AuthorsWatkins, R.E. / Davis-Searles, P.R. / Lambert, M.H. / Redinbo, M.R.
External linksJ. Mol. Biol. / PubMed:12909012
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1nrl:
Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SRL:
[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor / coactivator / PXR / xenobiotic / SRC-1 / ligand binding domain

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