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| Title | 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 45, Page 2388-2409, Year 2002 |
| Publish date | Apr 8, 2002 (structure data deposition date) |
 Authors | Bell, I.M. / Gallicchio, S.N. / Abrams, M. / Beese, L.S. / Beshore, D.C. / Bhimnathwala, H. / Bogusky, M.J. / Buser, C.A. / Culberson, J.C. / Davide, J. ...Bell, I.M. / Gallicchio, S.N. / Abrams, M. / Beese, L.S. / Beshore, D.C. / Bhimnathwala, H. / Bogusky, M.J. / Buser, C.A. / Culberson, J.C. / Davide, J. / Ellis-Hutchings, M. / Fernandes, C. / Gibbs, J.B. / Graham, S.L. / Hamilton, K.A. / Hartman, G.D. / Heimbrook, D.C. / Homnick, C.F. / Huber, H.E. / Huff, J.R. / Kassahun, K. / Koblan, K.S. / Kohl, N.E. / Lobell, R.B. / Lynch Jr., J.J. / Robinson, R. / Rodrigues, A.D. / Taylor, J.S. / Walsh, E.S. / Williams, T.M. / Zartman, C.B. |
 External links | J. Med. Chem. / PubMed:12036349 |
| Methods | X-ray diffraction |
| Resolution | 1.8 - 2 Å |
| Structure data |  PDB-1ld7:  PDB-1ld8: |
| Chemicals |  ChemComp-ZN:  ChemComp-FPP:  ChemComp-U66:  ChemComp-HOH:  ChemComp-ACY:  ChemComp-U49: |
| Source |
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 Keywords | TRANSFERASE / alpha-alpha barrel / inhibitor / ftase / pftase / fpp / caax / ras |
homo sapiens (human)