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Structure paper

TitleRefined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
Journal, issue, pagesJ. Mol. Biol., Vol. 232, Page 1101-1116, Year 1993
Publish dateJun 22, 1995 (structure data deposition date)
AuthorsFiner-Moore, J. / Fauman, E.B. / Foster, P.G. / Perry, K.M. / Santi, D.V. / Stroud, R.M.
External linksJ. Mol. Biol. / PubMed:8371269
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-1lca:
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1lcb:
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1lce:
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1thy:
REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-2tdm:
STRUCTURE OF THYMIDYLATE SYNTHASE
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-CB3:
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID

ChemComp-HOH:
WATER

ChemComp-TMP:
THYMIDINE-5'-PHOSPHATE

ChemComp-DHF:
DIHYDROFOLIC ACID

ChemComp-TMF:
5,10-METHYLENE-6-HYDROFOLIC ACID

Source
  • lactobacillus casei (bacteria)
KeywordsTRANSFERASE (METHYLTRANSFERASE) / NUCLEOTIDE SYNTHASE / TRANSFERASE(METHYLTRANSFERASE) / METHYLTRANSFERASE / TRANSFERASE

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