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TitleNovel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
Journal, issue, pagesJ. MED. CHEM., Vol. 45, Page 789-804, Year 2002
Publish dateDec 19, 2001 (structure data deposition date)
AuthorsSauerberg, P. / Pettersson, I. / Jeppesen, L. / Bury, P.S. / Mogensen, J.P. / Wassermann, K. / Brand, C.L. / Sturis, J. / Woldike, H.F. / Fleckner, J. ...Sauerberg, P. / Pettersson, I. / Jeppesen, L. / Bury, P.S. / Mogensen, J.P. / Wassermann, K. / Brand, C.L. / Sturis, J. / Woldike, H.F. / Fleckner, J. / Andersen, A.-S.T. / Mortensen, S.B. / Svensson, L.A. / Rasmussen, H.B. / Lehmann, S.V. / Polivka, Z. / Sindelar, K. / Panajotova, V. / Ynddal, L. / Wulff, E.M.
External linksJ. MED. CHEM. / PubMed:11831892
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1knu:
LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-YPA:
(S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / PPAR / NUCLEAR RECEPTOR / TRANSCRIPTION / GENE REGULATION / AGONIST COMPLEX

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