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Structure paper

TitleThe cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism
Journal, issue, pagesJ. Biol. Chem., Vol. 276, Page 48292-48299, Year 2001
Publish dateAug 19, 2001 (structure data deposition date)
AuthorsClare, P.M. / Poorman, R.A. / Kelley, L.C. / Watenpaugh, K.D. / Bannow, C.A. / Leach, K.L.
External linksPubMed:11604388
MethodsX-ray diffraction
Resolution1.96 Å
Structure data

PDB-1jsv:
The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-U55:
4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CDK2 / SERINE/THREONINE PROTEIN KINASE / CELL CYCLE / ATP-BINDING

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