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TitleStructural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Journal, issue, pagesNat. Struct. Biol., Vol. 8, Page 963-967, Year 2001
Publish dateAug 16, 2001 (structure data deposition date)
AuthorsBurkhard, P. / Dominici, P. / Borri-Voltattorni, C. / Jansonius, J.N. / Malashkevich, V.N.
External linksNat. Struct. Biol. / PubMed:11685243
MethodsX-ray diffraction
Resolution2.25 - 2.6 Å
Structure data

PDB-1js3:
Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-1js6:
Crystal Structure of DOPA decarboxylase
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-142:
CARBIDOPA / medication*YM

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsLYASE / DOPA decarboxylase / carbiDOPA / Parkinson's disease / Vitamin B6

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